Metabolic Regulation of Immune Responses

Regulation of Immune Responses By

Exosomes: Mediators of Immune Regulation

Extracellular Vesicles, including exosomes, are small membrane fragments released from many cell types, like Mesenchymal Stem Cells (MSCs). They were recognized as a mechanism of intercellular communication. They can transfer proteins, lipids and nucleic acids to other cells. Thus, they have many physiological (angiogenesis, coagulation and tissue repair, etc.) and pathological (e.g. in autoimm...

Regulation of immune responses by RBC transfusion

It has long been appreciated that transferring allogeneic tissues between members of the same species can have complicated effects upon the recipient immune system. Transfusion represents the most common exposure to large quantities of alloantigen, which unlike solid organ transplant, occurs in the absence of pharmacological immunosuppression. Transfused products constitute a complex cellular e...

Regulation of immune responses by prostaglandin E2.

PGE(2), an essential homeostatic factor, is also a key mediator of immunopathology in chronic infections and cancer. The impact of PGE(2) reflects the balance between its cyclooxygenase 2-regulated synthesis and 15-hydroxyprostaglandin dehydrogenase-driven degradation and the pattern of expression of PGE(2) receptors. PGE(2) enhances its own production but suppresses acute inflammatory mediator...

Regulation of immune responses by T cells.

n engl j med 354;11 www.nejm.org march 16, 2006 1166 From the Departments of Medicine (H.J., L.C.) and Pathology and Cell Biology (L.C.), Columbia University College of Physicians and Surgeons, New York. Address reprint requests to Dr. Jiang at the Department of Medicine (Rheumatology), Columbia University College of Physicians and Surgeons, 630 W. 168th St., New York, NY 10032, or at hj4@colum...